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While nuclear factor erythroid 2-related factor 2 (NRF2) and CCAAT/Enhancer Binding Protein (CEBP) also contribute to a minor increase in CHAC1 transcription, their roles are less pronounced compared to ATF4 ( FIGURE 4 ATF4 and ATF3 regulate CHAC1 expression by binding to specific sites within its promoter, the ATF/cAMP response element (CRE) at position 267 and the ATF/CRE modifier (ACM) motif at 248
PMID: 41844462 Ahmed F et al
This mechanism is applicable to other OTUD5-associated TRIP12 substrates
10.1039/c5lc00706b 23 RenN.LiuQ.YanL.HuangQ
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